The term is frequently used informally to refer to any combination of the enantiomers, or to either of them alone. Historically, it has been used to treat nasal congestion and depression. Amphetamine is also used as an athletic performance enhancer and cognitive enhancer, and recreationally as an aphrodisiac and euphoriant.

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Absorption and onset is generally much more rapid than oral and, as a result, a substance feels much more intense and is often shorter acting than if taken orally.

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