Unlike amphetamine, methamphetamine is neurotoxic to human midbrain dopaminergic neurons.[20] It has also been shown to damage serotonin neurons in the CNS. This damage includes adverse changes in brain structure and function, such as reductions in grey matter volume in several brain regions and adverse changes in markers of metabolic integrity.

Such a fundamental change in chronophilia would require more than changing sex hormones, but actual physical changes to the parts of the brain which control sexual attractions . There is no evidence of these differences in correctly sampled populations, despite multiple brain imaging studies.

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It belongs to a class of medications called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect. It works by enhancing the effects of a certain natural chemical in the body.